Although the participation of spliceosomes is almost always required for intron removal, a few types of genes have self-splicing RNA introns. The RNA transcript of such a gene can carry out the entire ...

Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have improved in recent years, approximately 30% of patients relapse following ...

A new study has revealed how a natural compound in our cells can reverse brain deficits in animal models of Alzheimer’s disease. The research shows that boosting levels of a molecule called NAD+ ...

In this contribution, the authors investigate the degree of alternative splicing across the evolutionary tree, and identify a trend of increasing alternative splicing as you move from the base of the ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

ABSTRACT: Coronary heart disease complicated with depression is one of the most common “psychosomatic heart diseases” in clinical practice. Its pathogenesis is complex and not yet fully clarified, and ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. The present study aimed to investigate the potential ...

In plants, pre-mRNA alternative splicing has been demonstrated to be a crucial tier that regulates gene expression in response to salt stress. However, the underlying mechanisms remain elusive. Here, ...

Collaboration with UMass Chan Medical School confirmed FMR1-217 as well as an RNA-targeted mechanism to restore functional FMRP protein to develop potential treatments for FXS QurAlis’ preliminary ...

Cancer disrupts RNA splicing by suppressing poison exons, leading to uncontrolled tumor growth. Researchers at JAX and UConn Health found that targeting TRA2β RNA with antisense oligonucleotides (ASOs ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...