The genomes of phages—viruses that infect bacteria—are largely composed of "dark matter": genes that encode proteins whose functions remain unknown. Less than four years ago, a team led by Prof. Rotem ...

Two parallel experiments in protein self-assembly produced strikingly different results, demonstrating that protein designers ...

A new study suggests Alzheimer’s disease may be detectable through subtle shape changes in proteins found in the blood.

This important study analyzed the impact of amino acid homorepeats on protein expression and solubility in yeast and E. coli. The authors provided convincing evidence that hydrophobic and positively ...

Chung’s group captured the transition period directly by improving the time resolution of a method called single-molecule ...

Scientists developed Evo 2, a large biological foundation model trained on about 9 trillion DNA base pairs that can analyse ...

PXMeter is a comprehensive toolkit for evaluating the quality of structures generated by biomolecular structure prediction models, with support for proteins, nucleic acids, and small molecules. Local ...

Abstract: RNA binding proteins (RBPs) play a crucial role in regulating biological functions through their interactions with specific RNAs, significantly impacting various life processes.

Predict the 3D spatial coordinates (x, y, z) of the C1' atom for every residue in a given RNA sequence. The model must generate 5 distinct structural conformations to account for RNA flexibility.

Abstract: Accurately predicting dangerous protein changes is essential for precision medicine and understanding genetic disorders. This paper lays the foundation for the eventual integration of ...