An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

When scientists first came across p53 in 1979, it was an intriguing but not Earth-shattering discovery. Six groups independently discovered a cellular protein with a molecular weight of roughly 53 ...

Each year, 20 million people are diagnosed with cancer. Various organs can be affected, and cancer types sometimes differ ...

Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes. Mutations in tumor suppressor genes can allow tumors to ...

Researchers have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the ...

Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma. CAFs enhance the malignant features of nearby cancer cells, increasing the likelihood of metastasis. P53 is a protein ...

The p53 gene plays an important role in cell biology as it regulates the cell cycle and halts the formation of tumors. While the gene was discovered more than four decades ago, researchers are still ...

The p53 protein plays a significant role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long dubbed the protein p53 as the “guardian of the genome,” ...

The p53 transcription factor is best known as a tumor suppressor but also plays fundamental roles in aging, metabolism, and stem cell biology. A naturally occurring p53 isoform, called Δ40p53 (or ...